Abstract The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD).Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlation between GERD and asthma of 0.18 and bidirectional PRS Moleskin Gilets and phenotypic associations ranging between OR 1.09-1.
14 and no correlations for eczema and allergic rhinitis.Linkage disequilibrium score regression is applied to summary statistics of recently published GERD and asthma/allergic disease genome wide association studies and reveals LAVENDER HAND a genetic correlation of 0.48 for asthma and GERD, and Genomic SEM supports a single latent factor.A gene-/gene-set analysis using MAGMA reveals six pleiotropic genes (two at 12q13.
2) associated with asthma and GERD.This study provides evidence that there is a common genetic architecture unique to asthma and GERD that may explain comorbidity and requires further investigation.